학술논문
An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer
Document Type
article
Author
Adrian Vallejo; Naiara Perurena; Elisabet Guruceaga; Pawel K. Mazur; Susana Martinez-Canarias; Carolina Zandueta; Karmele Valencia; Andrea Arricibita; Dana Gwinn; Leanne C. Sayles; Chen-Hua Chuang; Laura Guembe; Peter Bailey; David K. Chang; Andrew Biankin; Mariano Ponz-Sarvise; Jesper B. Andersen; Purvesh Khatri; Aline Bozec; E. Alejandro Sweet-Cordero; Julien Sage; Fernando Lecanda; Silve Vicent
Source
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
KRAS-driven cancers remain refractory to current clinical therapies. In this study, the authors show that lung and pancreatic cancers expressing oncogenic KRAS can be targeted by genetic inhibition of FOSL1, which involves downregulation of genes of the mitotic machinery.