학술논문
Diffuse alveolar hemorrhage in childhood-onset systemic lupus erythematosus: a severe disease flare with serious outcome
Document Type
article
Author
Gabriela Blay; Joaquim C. Rodrigues; Juliana C. O. Ferreira; Gabriela N. Leal; Natali W. Gormezano; Glaucia V. Novak; Rosa M. R. Pereira; Maria T. Terreri; Claudia S. Magalhães; Beatriz C. Molinari; Ana P. Sakamoto; Nadia E. Aikawa; Lucia M. A. Campos; Taciana A. P. Fernandes; Gleice Clemente; Octavio A. B. Peracchi; Vanessa Bugni; Roberto Marini; Silvana B. Sacchetti; Luciana M. Carvalho; Melissa M. Fraga; Tânia C. M. Castro; Valéria C. Ramos; Eloisa Bonfá; Clovis A. Silva; Brazilian Childhood-onset Systemic Lupus Erythematosus Group
Source
Advances in Rheumatology, Vol 58, Iss 1, Pp 1-6 (2018)
Subject
Language
English
ISSN
2523-3106
Abstract
Abstract Objective To evaluate prevalence, clinical manifestations, laboratory abnormalities and treatment in a multicenter cohort study including 847 childhood-onset systemic lupus erythematosus (cSLE) patients with and without diffuse alveolar hemorrhage (DAH), as well as concomitant parameters of severity. Methods DAH was defined as the presence of at least three respiratory symptoms/signs associated with diffuse interstitial/alveolar infiltrates on chest x-ray or high-resolution computer tomography and sudden drop in hemoglobin levels. Statistical analysis was performed using Bonferroni correction (p