학술논문
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
Document Type
article
Author
Alexander Teumer; Yong Li; Sahar Ghasemi; Bram P. Prins; Matthias Wuttke; Tobias Hermle; Ayush Giri; Karsten B. Sieber; Chengxiang Qiu; Holger Kirsten; Adrienne Tin; Audrey Y. Chu; Nisha Bansal; Mary F. Feitosa; Lihua Wang; Jin-Fang Chai; Massimiliano Cocca; Christian Fuchsberger; Mathias Gorski; Anselm Hoppmann; Katrin Horn; Man Li; Jonathan Marten; Damia Noce; Teresa Nutile; Sanaz Sedaghat; Gardar Sveinbjornsson; Bamidele O. Tayo; Peter J. van der Most; Yizhe Xu; Zhi Yu; Lea Gerstner; Johan Ärnlöv; Stephan J. L. Bakker; Daniela Baptista; Mary L. Biggs; Eric Boerwinkle; Hermann Brenner; Ralph Burkhardt; Robert J. Carroll; Miao-Li Chee; Miao-Ling Chee; Mengmeng Chen; Ching-Yu Cheng; James P. Cook; Josef Coresh; Tanguy Corre; John Danesh; Martin H. de Borst; Alessandro De Grandi; Renée de Mutsert; Aiko P. J. de Vries; Frauke Degenhardt; Katalin Dittrich; Jasmin Divers; Kai-Uwe Eckardt; Georg Ehret; Karlhans Endlich; Janine F. Felix; Oscar H. Franco; Andre Franke; Barry I. Freedman; Sandra Freitag-Wolf; Ron T. Gansevoort; Vilmantas Giedraitis; Martin Gögele; Franziska Grundner-Culemann; Daniel F. Gudbjartsson; Vilmundur Gudnason; Pavel Hamet; Tamara B. Harris; Andrew A. Hicks; Hilma Holm; Valencia Hui Xian Foo; Shih-Jen Hwang; M. Arfan Ikram; Erik Ingelsson; Vincent W. V. Jaddoe; Johanna Jakobsdottir; Navya Shilpa Josyula; Bettina Jung; Mika Kähönen; Chiea-Chuen Khor; Wieland Kiess; Wolfgang Koenig; Antje Körner; Peter Kovacs; Holly Kramer; Bernhard K. Krämer; Florian Kronenberg; Leslie A. Lange; Carl D. Langefeld; Jeannette Jen-Mai Lee; Terho Lehtimäki; Wolfgang Lieb; Su-Chi Lim; Lars Lind; Cecilia M. Lindgren; Jianjun Liu; Markus Loeffler; Leo-Pekka Lyytikäinen; Anubha Mahajan; Joseph C. Maranville; Deborah Mascalzoni; Barbara McMullen; Christa Meisinger; Thomas Meitinger; Kozeta Miliku; Dennis O. Mook-Kanamori; Martina Müller-Nurasyid; Josyf C. Mychaleckyj; Matthias Nauck; Kjell Nikus; Boting Ning; Raymond Noordam; Jeffrey O’ Connell; Isleifur Olafsson; Nicholette D. Palmer; Annette Peters; Anna I. Podgornaia; Belen Ponte; Tanja Poulain; Peter P. Pramstaller; Ton J. Rabelink; Laura M. Raffield; Dermot F. Reilly; Rainer Rettig; Myriam Rheinberger; Kenneth M. Rice; Fernando Rivadeneira; Heiko Runz; Kathleen A. Ryan; Charumathi Sabanayagam; Kai-Uwe Saum; Ben Schöttker; Christian M. Shaffer; Yuan Shi; Albert V. Smith; Konstantin Strauch; Michael Stumvoll; Benjamin B. Sun; Silke Szymczak; E-Shyong Tai; Nicholas Y. Q. Tan; Kent D. Taylor; Andrej Teren; Yih-Chung Tham; Joachim Thiery; Chris H. L. Thio; Hauke Thomsen; Unnur Thorsteinsdottir; Anke Tönjes; Johanne Tremblay; André G. Uitterlinden; Pim van der Harst; Niek Verweij; Suzanne Vogelezang; Uwe Völker; Melanie Waldenberger; Chaolong Wang; Otis D. Wilson; Charlene Wong; Tien-Yin Wong; Qiong Yang; Masayuki Yasuda; Shreeram Akilesh; Murielle Bochud; Carsten A. Böger; Olivier Devuyst; Todd L. Edwards; Kevin Ho; Andrew P. Morris; Afshin Parsa; Sarah A. Pendergrass; Bruce M. Psaty; Jerome I. Rotter; Kari Stefansson; James G. Wilson; Katalin Susztak; Harold Snieder; Iris M. Heid; Markus Scholz; Adam S. Butterworth; Adriana M. Hung; Cristian Pattaro; Anna Köttgen
Source
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.