학술논문
Linkage analysis identifies novel genetic modifiers of microbiome traits in families with inflammatory bowel disease
Document Type
article
Author
Source
Gut Microbes, Vol 14, Iss 1 (2022)
Subject
Language
English
ISSN
1949-0976
1949-0984
19490976
1949-0984
19490976
Abstract
Dysbiosis of the gut microbiome is a hallmark of inflammatory bowel disease (IBD) and both, IBD risk and microbiome composition, have been found to be associated with genetic variation. Using data from families of IBD patients, we examined the association between genetic and microbiome similarity in a specific IBD context, followed by a genome-wide quantitative trait locus (QTL) linkage analysis of various microbiome traits using the same data. SNP genotypes as well as gut microbiome and phenotype data were obtained from the Kiel IBD family cohort (IBD-KC). The IBD-KC is an ongoing prospective study in Germany currently comprising 256 families with 455 IBD patients and 575 first- and second-degree relatives. Initially focusing upon known IBD risk loci, we noted a statistically significant (FDR