학술논문
Urinary 8-hydroxy-2′-deoxyguanosine levels and preterm births: a prospective cohort study from the Japan Environment and Children’s Study
Document Type
article
Author
Zentaro Yamagata; Mitsuaki Hosoya; Hiroyasu Iso; Takeo Nakayama; Reiko Kishi; Nobuo Yaegashi; Shuichi Ito; Koichi Kusuhara; Hidekuni Inadera; Michihiro Kamijima; Yukihiro Ohya; Koichi Hashimoto; Chisato Mori; Masayuki Shima; Narufumi Suganuma; Takahiko Katoh; Shin Yamazaki; Seiji Yasumura; Youichi Kurozawa; Tsuyoshi Murata; Hyo Kyozuka; Toma Fukuda; Aya Kanno; Shun Yasuda; Akiko Yamaguchi; Akiko Sato; Yuka Ogata; Kosei Shinoki; Hidekazu Nishigori; Keiya Fujimori; Karin Imaizumi; Hirotaka Isogami
Source
BMJ Open, Vol 14, Iss 2 (2024)
Subject
Language
English
ISSN
2044-6055
Abstract
Objectives To evaluate the association between urinary 8-hydroxy-2′-deoxyguanosine (U8-OHdG) level—a marker of oxidative stress—and the incidence of preterm births (PTBs).Design Prospective cohort study.Setting The Japan Environment and Children’s Study (JECS).Participants Data from 92 715 women with singleton pregnancies at and after 22 weeks of gestation who were enrolled in the JECS, a nationwide birth cohort study, between 2011 and 2014 were analysed. U8-OHdG levels were assessed once in the second/third trimester using liquid chromatography–tandem mass spectrometry. Participants were categorised into the following three or five groups: low (