학술논문
The covariant structural and functional neuro-correlates of cognitive impairments in patients with end-stage renal diseases
Document Type
article
Author
Source
Frontiers in Neuroscience, Vol 18 (2024)
Subject
Language
English
ISSN
1662-453X
Abstract
IntroductionCognitive impairment (CI) is a common complication of end-stage renal disease (ESRD) that is associated with structural and functional changes in the brain. However, whether a joint structural and functional alteration pattern exists that is related to CI in ESRD is unclear.MethodsIn this study, instead of looking at brain structure and function separately, we aim to investigate the covariant characteristics of both functional and structural aspects. Specifically, we took the fusion analysis approach, namely, multimodal canonical correlation analysis and joint independent component analysis (mCCA+jICA), to jointly study the discriminative features in gray matter volume (GMV) measured by T1-weighted (T1w) MRI, fractional anisotropy (FA) in white matter measured by diffusion MRI, and the amplitude of low-frequency fluctuation (ALFF) measured by blood oxygenation-level-dependent (BOLD) MRI in 78 ESRD patients versus 64 healthy controls (HCs), followed by a mediation effect analysis to explore the relationship between neuroimaging findings, cognitive impairments and uremic toxins.ResultsTwo joint group-discriminative independent components (ICs) were found to show covariant abnormalities across FA, GMV, and ALFF (all p