학술논문
Role of magnifying endoscopy with narrow‐band imaging in the diagnosis of noninvasive gastric neoplasia
Document Type
article
Author
Keisuke Tanaka; Shinya Maekawa; Takashi Yoshida; Tatsuya Yamaguchi; Shinichi Takano; Shuya Matsuda; Hiroshi Hayakawa; Yasuaki Ishida; Masaru Muraoka; Satoshi Kawakami; Yoshimitsu Fukasawa; Toru Kuno; Fumihiko Iwamoto; Yuya Tsukui; Shoji Kobayashi; Yukiko Asakawa; Hiroko Shindo; Mitsuharu Fukasawa; Yasuhiro Nakayama; Taisuke Inoue; Tomoyoshi Uetake; Masahiko Ohtaka; Tadashi Sato; Kunio Mochizuki; Nobuyuki Enomoto
Source
JGH Open, Vol 5, Iss 4, Pp 446-453 (2021)
Subject
Language
English
ISSN
2397-9070
Abstract
Abstract Background and Aim There are no globally approved, distinguishing criteria enabling the classification of gastric adenomas and intramucosal carcinomas for differential diagnosis of noninvasive neoplasia (NIN). Methods Next‐generation sequencing of 50 cancer‐related genes was undertaken on 68 pathologically diagnosed microdissected gastric neoplasms (25 adenomas, 27 intramucosal carcinomas, and 16 submucosal carcinomas) obtained during endoscopic submucosal dissection. Findings from magnifying endoscopy with narrow‐band imaging (M‐NBI) of 52 NINs (the 25 adenomas and 27 intramucosal carcinomas) were compared with these data. Results Among all 68 neoplasms, the most frequently mutated genes were APC (76% in adenoma, 11.1% in intramucosal carcinoma, and 0% in submucosal carcinoma; P