학술논문
Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium
Document Type
article
Author
Ivan Cokic; Shing Fai Chan; Xingmin Guan; Anand R. Nair; Hsin-Jung Yang; Ting Liu; Yinyin Chen; Diego Hernando; Jane Sykes; Richard Tang; John Butler; Alice Dohnalkova; Libor Kovarik; Robert Finney; Avinash Kali; Behzad Sharif; Louis S. Bouchard; Rajesh Gupta; Mayil Singaram Krishnam; Keyur Vora; Balaji Tamarappoo; Andrew G. Howarth; Andreas Kumar; Joseph Francis; Scott B. Reeder; John C. Wood; Frank S. Prato; Rohan Dharmakumar
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
It is unclear why hemorrhagic myocardial infarctions (hMI) are destined for adverse outcomes. Here, the authors show that hMI drives fatty degeneration of infarct territories and contributes to adverse remodeling of the heart, which can be mitigated via timely depletion of iron within the hMI zone.