학술논문
The distribution of the modified Rankin scale scores change according to eligibility criteria in acute ischemic stroke trials: A consideration for sample size calculations when using ordinal regression analysis
Document Type
article
Author
Source
Contemporary Clinical Trials Communications, Vol 5, Iss C, Pp 133-136 (2017)
Subject
Language
English
ISSN
2451-8654
Abstract
Background: Distribution shifts of the modified Rankin scale (mRs) is used as outcome measure in acute ischemic stroke (AIS) randomized controlled trials (RCT). Distribution across strata of mRs is relevant for sample size calculations and may be affected by eligibility criteria. Aim: We aimed to assess the distribution of mRs scores across its different strata in AIS according to usual eligibility criteria. Methods: We computed follow-up mRs strata distribution between an unselected cohort and samples with (a) time from symptom onset 3 and