학술논문
Harnessing synthetic lethality to predict the response to cancer treatment
Document Type
article
Author
Joo Sang Lee; Avinash Das; Livnat Jerby-Arnon; Rand Arafeh; Noam Auslander; Matthew Davidson; Lynn McGarry; Daniel James; Arnaud Amzallag; Seung Gu Park; Kuoyuan Cheng; Welles Robinson; Dikla Atias; Chani Stossel; Ella Buzhor; Gidi Stein; Joshua J. Waterfall; Paul S. Meltzer; Talia Golan; Sridhar Hannenhalli; Eyal Gottlieb; Cyril H. Benes; Yardena Samuels; Emma Shanks; Eytan Ruppin
Source
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Synthetic lethality (SL) offers a new precision oncology approach, which is based on targeting cancer-specific vulnerabilities across the whole genome, going beyond cancer drivers. The authors develop an approach termed ISLE to identify clinically relevant SL interactions and use them for patient stratification and novel target identification.