학술논문
Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile
Document Type
article
Author
Source
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Malawsky, Weir et al. compare medulloblastomas that form in mice engineered to express SmoM2, a constitutively active component of the Sonic hedgehog signaling pathway, starting in either neural progenitor or stem cells. Medulloblastomas in the two models show similar bulk transcriptomic profiles, but contain different fractions of tumor stem cells and different myeloid populations, and demonstrate different therapeutic responses.