학술논문
Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway
Document Type
article
Author
Kevin Alicea-Torres; Emilio Sanseviero; Jun Gui; Jinyun Chen; Filippo Veglia; Qiujin Yu; Laxminarasimha Donthireddy; Andrew Kossenkov; Cindy Lin; Shuyu Fu; Charles Mulligan; Brian Nam; Gregory Masters; Fred Denstman; Joseph Bennett; Neil Hockstein; Agnieszka Rynda-Apple; Yulia Nefedova; Serge Y. Fuchs; Dmitry I. Gabrilovich
Source
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The role of type I interferon signalling in the control of myeloid derived suppressor cells (MDSC) activity remains controversial. Here the authors show that downregulation of type I interferon receptor is observed in MDSC from cancer patients and tumor-bearing mice and is required for the activation of their immune suppressive properties.