학술논문
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors
Document Type
article
Author
Source
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The essential SARS-CoV-2 3CL protease is of interest as a drug target. Here, the authors identify three 3CL inhibitors and characterize them both in vitro and with a cell-based assay, and they also present the inhibitor-bound 3CL crystal structures, which may allow for the design of improved compounds.