학술논문
Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study
Document Type
article
Author
Gamze Erzin; Lotta-Katrin Pries; Jim van Os; Laura Fusar-Poli; Philippe Delespaul; Gunter Kenis; Jurjen J. Luykx; Bochao D. Lin; Alexander L. Richards; Berna Akdede; Tolga Binbay; Vesile Altınyazar; Berna Yalınçetin; Güvem Gümüş-Akay; Burçin Cihan; Haldun Soygür; Halis Ulaş; Eylem Şahin Cankurtaran; Semra Ulusoy Kaymak; Marina M. Mihaljevic; Sanja Andric-Petrovic; Tijana Mirjanic; Miguel Bernardo; Gisela Mezquida; Silvia Amoretti; Julio Bobes; Pilar A. Saiz; Maria Paz García-Portilla; Julio Sanjuan; Eduardo J. Aguilar; Jose Luis Santos; Estela Jiménez-López; Manuel Arrojo; Angel Carracedo; Gonzalo López; Javier González-Peñas; Mara Parellada; Nadja P. Maric; Cem Atbaşoğlu; Alp Ucok; Köksal Alptekin; Meram Can Saka; Celso Arango; Micheal C. O’Donovan; Bart P. F. Rutten; Sinan Guloksuz
Source
European Psychiatry, Vol 64 (2021)
Subject
Language
English
ISSN
0924-9338
1778-3585
1778-3585
Abstract
AbstractBackgroundA cumulative environmental exposure score for schizophrenia (exposome score for schizophrenia [ES-SCZ]) may provide potential utility for risk stratification and outcome prediction. Here, we investigated whether ES-SCZ was associated with functioning in patients with schizophrenia spectrum disorder, unaffected siblings, and healthy controls.MethodsThis cross-sectional sample consisted of 1,261 patients, 1,282 unaffected siblings, and 1,525 healthy controls. The Global Assessment of Functioning (GAF) scale was used to assess functioning. ES-SCZ was calculated based on our previously validated method. The association between ES-SCZ and the GAF dimensions (symptom and disability) was analyzed by applying regression models in each group (patients, siblings, and controls). Additional models included polygenic risk score for schizophrenia (PRS-SCZ) as a covariate.ResultsES-SCZ was associated with the GAF dimensions in patients (symptom: B = −1.53, p-value = 0.001; disability: B = −1.44, p-value = 0.001), siblings (symptom: B = −3.07, p-value