학술논문
Intratumoral heterogeneity and clonal evolution in liver cancer
Document Type
article
Author
Bojan Losic; Amanda J. Craig; Carlos Villacorta-Martin; Sebastiao N. Martins-Filho; Nicholas Akers; Xintong Chen; Mehmet E. Ahsen; Johann von Felden; Ismail Labgaa; Delia DʹAvola; Kimaada Allette; Sergio A. Lira; Glaucia C. Furtado; Teresa Garcia-Lezana; Paula Restrepo; Ashley Stueck; Stephen C. Ward; Maria I. Fiel; Spiros P. Hiotis; Ganesh Gunasekaran; Daniela Sia; Eric E. Schadt; Robert Sebra; Myron Schwartz; Josep M. Llovet; Swan Thung; Gustavo Stolovitzky; Augusto Villanueva
Source
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Immune-mediated selection pressures impact the clonal evolution of tumours. Here, in hepatocellular carcinoma the authors map spatio-temporal interactions between tumor and immune cells, highlighting the regulatory substrate of intra-tumoural heterogeneity that correlates with regional adaptive immune responses.