학술논문
Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice
Document Type
article
Author
Eunee Lee; Seungjoon Lee; Jae Jin Shin; Woochul Choi; Changuk Chung; Suho Lee; Jihye Kim; Seungmin Ha; Ryunhee Kim; Taesun Yoo; Ye-Eun Yoo; Jisoo Kim; Young Woo Noh; Issac Rhim; Soo Yeon Lee; Woohyun Kim; Taekyung Lee; Hyogeun Shin; Il-Joo Cho; Karl Deisseroth; Sang Jeong Kim; Joo Min Park; Min Whan Jung; Se-Bum Paik; Eunjoon Kim
Source
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
How NMDAR and GABA neuronal dysfunctions result in impaired social behaviour is unclear. Here, the authors show that NMDARs and gap junctions in cortical PV interneurons modulate burst firing, affecting social behaviour.