학술논문
Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study
Document Type
article
Author
Surina Singh; Ananyo Choudhury; Scott Hazelhurst; Nigel J. Crowther; Palwendé R. Boua; Hermann Sorgho; Godfred Agongo; Engelbert A. Nonterah; Lisa K. Micklesfield; Shane A. Norris; Isaac Kisiangani; Shukri Mohamed; Francesc X. Gómez-Olivé; Stephen M. Tollman; Solomon Choma; J-T. Brandenburg; Michèle Ramsay
Source
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Abstract Most hypertension-related genome-wide association studies (GWASs) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study GWAS meta-analysis for blood pressure (BP)-related traits (systolic and diastolic BP, pulse pressure, mean-arterial pressure and hypertension) from three sub-Saharan African geographic regions (N = 10,775), identifies two novel genome-wide significant signals (p