학술논문
Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease
Document Type
article
Author
Scott E. Youlten; John P. Kemp; John G. Logan; Elena J. Ghirardello; Claudio M. Sergio; Michael R. G. Dack; Siobhan E. Guilfoyle; Victoria D. Leitch; Natalie C. Butterfield; Davide Komla-Ebri; Ryan C. Chai; Alexander P. Corr; James T. Smith; Sindhu T. Mohanty; John A. Morris; Michelle M. McDonald; Julian M. W. Quinn; Amelia R. McGlade; Nenad Bartonicek; Matt Jansson; Konstantinos Hatzikotoulas; Melita D. Irving; Ana Beleza-Meireles; Fernando Rivadeneira; Emma Duncan; J. Brent Richards; David J. Adams; Christopher J. Lelliott; Robert Brink; Tri Giang Phan; John A. Eisman; David M. Evans; Eleftheria Zeggini; Paul A. Baldock; J. H. Duncan Bassett; Graham R. Williams; Peter I. Croucher
Source
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal disorders and common complex skeletal diseases.