학술논문
Clinical potential of bevacizumab in the treatment of metastatic and locally advanced cervical cancer: current evidence
Document Type
article
Author
Source
OncoTargets and Therapy, Vol 2014, Iss default, Pp 751-759 (2014)
Subject
Language
English
ISSN
1178-6930
Abstract
Matthew W Jackson, Chad G Rusthoven, Christine M Fisher, Tracey E SchefterDepartment of Radiation Oncology, University of Colorado, Denver, CO, USAAbstract: The addition of bevacizumab to established therapies for metastatic and locally advanced cervical cancer is an area of evolving research and a potential strategy toward improving historically suboptimal outcomes for women with advanced disease. Bevacizumab, when added to first-line chemotherapy, has now been shown to improve overall survival among women with metastatic cervical cancer, and recent Phase II data suggests it is safe and effective for patients with locally advanced disease treated with curative intent. Here we review the rationale and current evidence for bevacizumab in clinical practice, with an emphasis on the emerging role of bevacizumab in the treatment of metastatic and locally advanced cervical cancer.Keywords: bevacizumab, Avastin®, advanced cervical cancer, metastatic cervical cancer