학술논문
Age-of-onset information helps identify 76 genetic variants associated with allergic disease.
Document Type
article
Author
Manuel A R Ferreira; Judith M Vonk; Hansjörg Baurecht; Ingo Marenholz; Chao Tian; Joshua D Hoffman; Quinta Helmer; Annika Tillander; Vilhelmina Ullemar; Yi Lu; Sarah Grosche; Franz Rüschendorf; Raquel Granell; Ben M Brumpton; Lars G Fritsche; Laxmi Bhatta; Maiken E Gabrielsen; Jonas B Nielsen; Wei Zhou; Kristian Hveem; Arnulf Langhammer; Oddgeir L Holmen; Mari Løset; Gonçalo R Abecasis; Cristen J Willer; Nima C Emami; Taylor B Cavazos; John S Witte; Agnieszka Szwajda; andMe Research Team; collaborators of the SHARE study; David A Hinds; Norbert Hübner; Stephan Weidinger; Patrik Ke Magnusson; Eric Jorgenson; Robert Karlsson; Lavinia Paternoster; Dorret I Boomsma; Catarina Almqvist; Young-Ae Lee; Gerard H Koppelman
Source
PLoS Genetics, Vol 16, Iss 6, p e1008725 (2020)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which symptoms of allergic disease first develop, considering information from asthma, hay fever and eczema. Self-reported age-of-onset information was available for 117,130 genotyped individuals of European ancestry from the UK Biobank study. For each individual, we identified the earliest age at which asthma, hay fever and/or eczema was first diagnosed and performed a genome-wide association study (GWAS) of this combined age-of-onset phenotype. We identified 50 variants with a significant independent association (P