학술논문
MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma
Document Type
article
Author
Sean T. Bailey; Aleisha M. Smith; Jordan Kardos; Sara E. Wobker; Harper L. Wilson; Bhavani Krishnan; Ryoichi Saito; Hyo Jin Lee; Jing Zhang; Samuel C. Eaton; Lindsay A. Williams; Ujjawal Manocha; Dorien J. Peters; Xinchao Pan; Thomas J. Carroll; Dean W. Felsher; Vonn Walter; Qing Zhang; Joel S. Parker; Jen Jen Yeh; Richard A. Moffitt; Janet Y. Leung; William Y. Kim
Source
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Renal cell carcinoma (RCC) is a common and aggressive malignancy. Here, the authors generate two mouse models of the most common RCC subtypes: the human papillary RCC throughMYC activation and clear cell RCC through MYC activation combined with Vhl and Cdkn2adeletion.