학술논문
KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Neuronal identity maintenance is highly regulated. Here, the authors showed that CBP and p300 safeguard neuronal identity through histone acetylation at promoters and enhancers of neuronal specific genes. The loss of both CBP and p300 impairs gene expression, circuit activity, and behavior in mice.