학술논문
Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment
Document Type
article
Author
Diego Scheggia; Rosa Mastrogiacomo; Maddalena Mereu; Sara Sannino; Richard E. Straub; Marco Armando; Francesca Managò; Simone Guadagna; Fabrizio Piras; Fengyu Zhang; Joel E. Kleinman; Thomas M. Hyde; Sanne S. Kaalund; Maria Pontillo; Genny Orso; Carlo Caltagirone; Emiliana Borrelli; Maria A. De Luca; Stefano Vicari; Daniel R. Weinberger; Gianfranco Spalletta; Francesco Papaleo
Source
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Patients with schizophrenia show varied response to antipsychotics. Here, the authors demonstrate in patients under antipsychotics treatment that a haplotype associated with lower dysbindin-1 expression correlated with better executive functions, providing further mechanistic support from mouse models.