학술논문
Effects and mechanisms of mindfulness training and physical exercise on cognition, emotional wellbeing, and brain outcomes in chronic stroke patients: Study protocol of the MindFit project randomized controlled trial
Document Type
article
Author
Adrià Bermudo-Gallaguet; Mar Ariza; Rosalia Dacosta-Aguayo; Daniela Agudelo; Neus Camins-Vila; Maria Boldó; Òscar Carrera; Sandra Vidal; Blai Ferrer-Uris; Albert Busquets; Marc Via; Guillem Pera; Cynthia Cáceres; Meritxell Gomis; Alberto García-Molina; José María Tormos; Ana Arrabé; Gustavo Diez; Maria José Durà Mata; Pere Torán-Monserrat; Juan José Soriano-Raya; Sira Domènech; Alexandre Perera-Lluna; Kirk I. Erickson; Maria Mataró
Source
Frontiers in Aging Neuroscience, Vol 14 (2022)
Subject
Language
English
ISSN
1663-4365
Abstract
BackgroundPost-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computerized cognitive training (CCT) may benefit stroke patients by impacting neuroplasticity and brain health.Materials and methodsOne hundred and forty-one chronic stroke patients are randomly allocated to receive mindfulness-based stress reduction + CCT (n = 47), multicomponent PE program + CCT (n = 47), or CCT alone (n = 47). Interventions consist of 12-week home-based programs five days per week. Before and after the interventions, we collect data from cognitive, psychological, and physical tests, blood and stool samples, and structural and functional brain scans.ResultsThe effects of the interventions on cognitive and emotional outcomes will be described in intention-to-treat and per-protocol analyses. We will also explore potential mediators and moderators, such as genetic, molecular, brain, demographic, and clinical factors in our per-protocol sample.DiscussionThe MindFit Project is a randomized clinical trial that aims to assess the impact of mindfulness and PE combined with CCT on chronic stroke patients’ cognitive and emotional wellbeing. Furthermore, our design takes a multimodal biopsychosocial approach that will generate new knowledge at multiple levels of evidence, from molecular bases to behavioral changes.Clinical trial registrationwww.ClinicalTrials.gov, identifier NCT04759950.