학술논문
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
Document Type
article
Author
Inma M. Berenjeno; Roberto Piñeiro; Sandra D. Castillo; Wayne Pearce; Nicholas McGranahan; Sally M. Dewhurst; Valerie Meniel; Nicolai J. Birkbak; Evelyn Lau; Laurent Sansregret; Daniele Morelli; Nnennaya Kanu; Shankar Srinivas; Mariona Graupera; Victoria E. R. Parker; Karen G. Montgomery; Larissa S. Moniz; Cheryl L. Scudamore; Wayne A. Phillips; Robert K. Semple; Alan Clarke; Charles Swanton; Bart Vanhaesebroeck
Source
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Activated PI3K causes cancer, but the role of active PI3K mutations in early stages of malignancy are unclear. Here, the authors show in a mouse model that active PI3K induces centrosome amplification via AKT, ROCK, CDK2/Cyclin E and nucleophosmin, and increased tolerance of genome doubling.