학술논문
T cells with increased responsiveness cause obesity in mice without diet intervention
Document Type
article
Author
Ida Gregersen; Xiang Y. Kong; Sander Kooijman; Håvard Foyn; Helene Grannes; Maria B. Olsen; Anna M. Lone; Kuan Yang; Ana Quiles-Jiménez; Marianne Tran; Jonas Øgaard; Filip M. Segers; Azita Rashidi; Ellen Lund Sagen; Knut H. Lauritzen; Amanda C.M. Pronk; Jan Freark de Boer; Kirsten B. Holven; Espen Melum; Pål Aukrust; Kjetil Taskén; Sverre Holm; Patrick C.N. Rensen; Tuva B. Dahl; Bente Halvorsen
Source
iScience, Vol 27, Iss 4, Pp 109471- (2024)
Subject
Language
English
ISSN
2589-0042
Abstract
Summary: Obesity is a complex multicausal disease that can cause morbidity and mortality, and there is need for improved knowledge on the underlying mechanisms. Using a mouse model of increased T cell responsiveness, we show that development of obesity can be driven by immune cells. This was confirmed with bone marrow transplantation and adoptive T cell transfer to several recipient mouse models. Single-cell RNA sequencing and CyTOF analysis showed that the mice display altered composition of circulating T cells and increased T cell activation in visceral adipose tissue, suggesting activated T cells as critical players in the increased fat mass. In this study, we provide evidence that obesity can be driven by immune cell activity and in particular by T cells, which could have broad implications for prevention and treatment of this condition.