학술논문
SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
Document Type
article
Author
Source
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here Kang et al. show that the volume-regulated anion channel, SWELL1, is involved in glucose-stimulated calcium increase and insulin secretion.