학술논문
Ethnicity based differences in statin use and hypercholesterolemia control among patients with premature coronary artery disease-results of I-PAD study
Document Type
article
Author
Raheleh Karimi; Ehsan Zarepur; Alireza Khosravi; Noushin Mohammadifard; Fereidoon Nouhi; Hasan Alikhasi; Shima Nasirian; Masoumeh Sadeghi; Hamidreza Roohafza; Seyed Ali Moezi Bady; Parisa janjani; Kamal Solati; Masoud Lotfizadeh; Samad Ghaffari; Elmira Javanmardi; Mahboobeh Gholipour; Mostafa dehghani; Mostafa Cheraghi; Ahmadreza Assareh; Habib Haybar; Seyedeh Mahdieh Namayandeh; Reza madadi; Javad Kojuri; Marjan Mansourian; Nizal Sarrafzadegan
Source
International Journal of Cardiology. Cardiovascular Risk and Prevention, Vol 16, Iss , Pp 200168- (2023)
Subject
Language
English
ISSN
2772-4875
Abstract
Background: Statins use is the most important treatment for high LDL cholesterol in patients with premature coronary artery disease (CAD). Previous reports have shown racial and gender differences in statin use in the general population, but this wasn't studied in premature CAD based on different ethnicities. Methods and results: Our study includes 1917 men and women with confirmed diagnosis of premature CAD. Logistic regression model was used to evaluate the high LDL cholesterol control in the groups and the OR with 95% confidence interval (CI) was reported as the effect size. After adjustment for confounders, the odds of controlling LDL in women taking Lovastatin, Rosuvastatin, and Simvastatin were 0.27 (0.03, 0.45) lower in comparison with men. Also, in participant who took 3 types of statins, the odds of controlling LDL were significantly different between Lor and Arab compared with Fars ethnicity. After adjustment to all confounders (full model), the odds of controlling LDL were lower for Gilak in Lovastatin, Rosuvastatin, and Simvastatin by 0.64 (0.47, 0.75); 0.61 (0.43, 0.73); 0.63 (0.46, 0.74) respectively and higher for Arab in Lovastatin, Rosuvastatin, and Simvastatin by 4.63 (18.28, 0.73); 4.67 (17.47, 0.74); 4.55 (17.03, 0.71) respectively compared to Fars. Conclusions: Major differences in different gender and ethnicities may have had led to disparities in statin use and LDL control. Awareness of the statins impact on high LDL cholesterol based on different ethnicities can help health decision-makers to close the observed gaps in statin use and control LDL to prevent CAD problems.