학술논문
Anti-SMN autoantibodies in mixed connective tissue disease are associated with a severe systemic sclerosis phenotype
Document Type
article
Author
Source
RMD Open, Vol 9, Iss 4 (2023)
Subject
Language
English
ISSN
2056-5933
Abstract
Objectives The survival of motor neuron (SMN) complex has an essential role in the assembly of small nuclear ribonucleoproteins (RNP). Recent reports have described autoantibodies (aAbs) to the SMN complex as novel biomarkers in anti-U1RNP+ myositis patients. The aim of this study was to compare phenotypic features of anti-U1RNP+ mixed connective tissue disease (MCTD) patients with and without anti-SMN aAbs.Methods A retrospective MCTD cohort was studied. Addressable laser bead immunoassay was used to detect specific anti-SMN aAbs with