학술논문
Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition
Document Type
article
Author
Joanna L. Clasen; Rita Mabunda; Alicia K. Heath; Rudolf Kaaks; Verena Katzke; Matthias B. Schulze; Anna Birukov; Giovanna Tagliabue; Paolo Chiodini; Rosario Tumino; Lorenzo Milani; Tonje Braaten; Inger Gram; Marko Lukic; Leila Luján‐Barroso; Miguel Rodriguez‐Barranco; María‐Dolores Chirlaque; Eva Ardanaz; Pilar Amiano; Jonas Manjer; Linnea Huss; Börje Ljungberg; Ruth Travis; Karl Smith‐Byrne; Marc Gunter; Matthias Johansson; Sabina Rinaldi; Elisabete Weiderpass; Elio Riboli; Amanda J. Cross; David C. Muller
Source
Cancer Medicine, Vol 12, Iss 14, Pp 15588-15600 (2023)
Subject
Language
English
ISSN
2045-7634
Abstract
Abstract Background Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology. Materials & Methods We investigated associations of age at menarche and age at menopause, pregnancy‐related factors, hysterectomy and ovariectomy and exogenous hormone use with RCC risk among 298,042 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Results During 15 years of follow‐up, 438 RCC cases were identified. Parous women had higher rates of RCC compared with nulliparous women (HR = 1.71, 95% CI 1.18, 2.46), and women who were older at age of first pregnancy had lower rates of RCC (30 years + vs.