학술논문
An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking
Document Type
article
Author
Source
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
2399-3642
Abstract
The cytosolic tail of β-coronavirus spike proteins contains dibasic motifs that must be able to bind to the host’s coatomer protein-I (COPI) for trafficking and be released for viral assembly in the ER-Golgi intermediate compartment. The critical residues in both the spike cytosolic tail and COPI are identified that modulate the association-dissociation kinetics.