학술논문
Non-canonical functions of SNAIL drive context-specific cancer progression
Document Type
article
Author
Mariel C. Paul; Christian Schneeweis; Chiara Falcomatà; Chuan Shan; Daniel Rossmeisl; Stella Koutsouli; Christine Klement; Magdalena Zukowska; Sebastian A. Widholz; Moritz Jesinghaus; Konstanze K. Heuermann; Thomas Engleitner; Barbara Seidler; Katia Sleiman; Katja Steiger; Markus Tschurtschenthaler; Benjamin Walter; Sören A. Weidemann; Regina Pietsch; Angelika Schnieke; Roland M. Schmid; Maria S. Robles; Geoffroy Andrieux; Melanie Boerries; Roland Rad; Günter Schneider; Dieter Saur
Source
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
SNAIL promotes tumour metastasis through inducing epithelial to mesenchymal transition (EMT). Here the authors report that SNAIL bypasses senescence and regulates cell cycle progression to promote pancreatic carcinogenesis and this is independent of EMT induction.