학술논문
Kielin/chordin‐like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein‐2
Document Type
article
Source
FEBS Open Bio, Vol 13, Iss 7, Pp 1357-1364 (2023)
Subject
Language
English
ISSN
2211-5463
Abstract
Bone morphogenetic proteins (BMPs) play a key role in embryonic differentiation for osteoblast and bone formation. Kielin/chordin‐like protein (Kcp) is known to enhance the effects of BMP signaling. Here, we present ALP activity, gene expression, and calcification data demonstrating that Kcp affects the differentiation of C2C12 myoblasts into osteoblasts. We report that the presence of Kcp enhances the ability of BMP‐2 to induce the differentiation of C2C12 myoblasts into osteoblasts. Additionally, BMP‐2‐mediated stimulation of phosphorylated Smad1/5 was apparently enhanced in the presence of Kcp. The present findings may contribute to progression toward the clinical use of BMPs for treatment of bone fracture, osteoarthritis, and other similar conditions.