학술논문
Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases
Document Type
article
Author
Sanjay M. Prakadan; Christopher A. Alvarez-Breckenridge; Samuel C. Markson; Albert E. Kim; Robert H. Klein; Naema Nayyar; Andrew W. Navia; Benjamin M. Kuter; Kellie E. Kolb; Ivanna Bihun; Joana L. Mora; Mia Solana Bertalan; Brian Shaw; Michael White; Alexander Kaplan; Jackson H. Stocking; Marc H. Wadsworth; Eudocia Q. Lee; Ugonma Chukwueke; Nancy Wang; Megha Subramanian; Denisse Rotem; Daniel P. Cahill; Viktor A. Adalsteinsson; Jeffrey W. Miller; Ryan J. Sullivan; Scott L. Carter; Priscilla K. Brastianos; Alex K. Shalek
Source
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Leptomeningeal disease (LMD) is a serious complication of metastatic solid tumors with a poor prognosis. Here, by using single-cell RNA sequencing of cerebrospinal fluid, the authors report genomic and immune correlates of response to immunotherapy in two cohorts of patients with LMD treated with immune checkpoint inhibitors.