학술논문
STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming
Document Type
article
Author
Zhaowei Chu; Lei Gu; Yeguang Hu; Xiaoyang Zhang; Man Li; Jiajia Chen; Da Teng; Man Huang; Che-Hung Shen; Li Cai; Toshimi Yoshida; Yifeng Qi; Zhixin Niu; Austin Feng; Songmei Geng; Dennie T. Frederick; Emma Specht; Adriano Piris; Ryan J. Sullivan; Keith T. Flaherty; Genevieve M. Boland; Katia Georgopoulos; David Liu; Yang Shi; Bin Zheng
Source
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
STAG2 is a core subunit of the cohesin complex involved in DNA looping, but its transcriptional targets are largely unknown. Here the authors show STAG2 controls the 3D chromatin structure at the IRF9 locus to restrict IRF9 expression. Loss of STAG2 results in IRF9 activation, which in turn upregulates PD-L1 expression in cancer cells, suggesting a tumor suppressor function in immune evasion.