학술논문
CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammationResearch in context
Document Type
article
Author
Jingya Yan; Kavitha Kothur; Shekeeb Mohammad; Jason Chung; Shrujna Patel; Hannah F. Jones; Brooke A. Keating; Velda X. Han; Richard Webster; Simone Ardern-Holmes; Jayne Antony; Manoj P. Menezes; Esther Tantsis; Deepak Gill; Sachin Gupta; Tejaswi Kandula; Hugo Sampaio; Michelle A. Farrar; Christopher Troedson; P Ian Andrews; Sekhar C. Pillai; Benjamin Heng; Gilles J. Guillemin; Anna Guller; Sushil Bandodkar; Russell C. Dale
Source
EBioMedicine, Vol 91, Iss , Pp 104589- (2023)
Subject
Language
English
ISSN
2352-3964
Abstract
Summary: Background: Defining the presence of acute and chronic brain inflammation remains a challenge to clinicians due to the heterogeneity of clinical presentations and aetiologies. However, defining the presence of neuroinflammation, and monitoring the effects of therapy is important given its reversible and potentially damaging nature. We investigated the utility of CSF metabolites in the diagnosis of primary neuroinflammatory disorders such as encephalitis and explored the potential pathogenic role of inflammation in epilepsy. Methods: Cerebrospinal fluid (CSF) collected from 341 paediatric patients (169 males, median age 5.8 years, range 0.1–17.1) were examined. The patients were separated into a primary inflammatory disorder group (n = 90) and epilepsy group (n = 80), who were compared with three control groups including neurogenetic and structural (n = 76), neurodevelopmental disorders, psychiatric and functional neurological disorders (n = 63), and headache (n = 32). Findings: There were statistically significant increases of CSF neopterin, kynurenine, quinolinic acid and kynurenine/tryptophan ratio (KYN/TRP) in the inflammation group compared to all control groups (all p