학술논문
Breast cancer prevention by short-term inhibition of TGFβ signaling
Document Type
article
Author
Maša Alečković; Simona Cristea; Carlos R. Gil Del Alcazar; Pengze Yan; Lina Ding; Ethan D. Krop; Nicholas W. Harper; Ernesto Rojas Jimenez; Donghao Lu; Anushree C. Gulvady; Pierre Foidart; Marco Seehawer; Benedetto Diciaccio; Katherine C. Murphy; Jason Pyrdol; Jayati Anand; Kodie Garza; Kai W. Wucherpfennig; Rulla M. Tamimi; Franziska Michor; Kornelia Polyak
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
TGFβ signalling is reported to regulate hormone-responsive mammary epithelial progenitors that are associated with breast cancer risk. Here, the authors find that short-term TGFBR1 inhibition prevents tumour formation in rat breast cancer models and identify a TGFBR1 inhibition-responsive sub-population of mammary epithelial cells, which is associated with human breast cancer risk.