학술논문
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
Document Type
article
Author
Henry Nording; Lasse Baron; David Haberthür; Frederic Emschermann; Matthias Mezger; Manuela Sauter; Reinhard Sauter; Johannes Patzelt; Kai Knoepp; Anne Nording; Moritz Meusel; Roza Meyer-Saraei; Ruslan Hlushchuk; Daniel Sedding; Oliver Borst; Ingo Eitel; Christian M. Karsten; Robert Feil; Bernd Pichler; Jeanette Erdmann; Admar Verschoor; Emmanouil Chavakis; Triantafyllos Chavakis; Philipp von Hundelshausen; Jörg Köhl; Meinrad Gawaz; Harald F. Langer
Source
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
As more intersection points between platelets and the immune system are found, the role of platelets for vessel growth in the adult organism remains unclear. The authors demonstrate that platelets negatively modulate revascularization through CXCL4 secretion induced by activation C5aR1 on their surface.