학술논문
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
Document Type
article
Author
Molly Went; Amit Sud; Asta Försti; Britt-Marie Halvarsson; Niels Weinhold; Scott Kimber; Mark van Duin; Gudmar Thorleifsson; Amy Holroyd; David C. Johnson; Ni Li; Giulia Orlando; Philip J. Law; Mina Ali; Bowang Chen; Jonathan S. Mitchell; Daniel F. Gudbjartsson; Rowan Kuiper; Owen W. Stephens; Uta Bertsch; Peter Broderick; Chiara Campo; Obul R Bandapalli; Hermann Einsele; Walter A. Gregory; Urban Gullberg; Jens Hillengass; Per Hoffmann; Graham H. Jackson; Karl-Heinz Jöckel; Ellinor Johnsson; Sigurður Y. Kristinsson; Ulf-Henrik Mellqvist; Hareth Nahi; Douglas Easton; Paul Pharoah; Alison Dunning; Julian Peto; Federico Canzian; Anthony Swerdlow; Rosalind A. Eeles; ZSofia Kote-Jarai; Kenneth Muir; Nora Pashayan; Jolanta Nickel; Markus M. Nöthen; Thorunn Rafnar; Fiona M. Ross; Miguel Inacio da Silva Filho; Hauke Thomsen; Ingemar Turesson; Annette Vangsted; Niels Frost Andersen; Anders Waage; Brian A. Walker; Anna-Karin Wihlborg; Annemiek Broyl; Faith E. Davies; Unnur Thorsteinsdottir; Christian Langer; Markus Hansson; Hartmut Goldschmidt; Martin Kaiser; Pieter Sonneveld; Kari Stefansson; Gareth J. Morgan; Kari Hemminki; Björn Nilsson; Richard S. Houlston; The PRACTICAL consortium
Source
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Multiple myeloma is a cancer of the plasma cells, and the complete aetiology of the disease is still unclear. Here the authors perform an additional GWAS analysis followed by a meta-analysis with existing GWAS and replication genotyping and identify 6 novel risk loci and utilise gene expression, epigenetic profiling and in situ Hi-C data to further our understanding of MM susceptibility.