학술논문
Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance
Document Type
article
Author
Bin Zhu; Yanzi Xiao; Meredith Yeager; Gary Clifford; Nicolas Wentzensen; Michael Cullen; Joseph F. Boland; Sara Bass; Mia K. Steinberg; Tina Raine-Bennett; DongHyuk Lee; Robert D. Burk; Maisa Pinheiro; Lei Song; Michael Dean; Chase W. Nelson; Laurie Burdett; Kai Yu; David Roberson; Thomas Lorey; Silvia Franceschi; Philip E. Castle; Joan Walker; Rosemary Zuna; Mark Schiffman; Lisa Mirabello
Source
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
The APOBEC mutational signature is prevalent in different tumour types. Here, using HPV16- positive cervical samples, the authors show that the signature is more prevalent in the viral genome of benign or clearing HPV16 infections compared to the viral genomes of the more advanced precancerous lesions or cervical cancer.