학술논문
MICU1 drives glycolysis and chemoresistance in ovarian cancer
Document Type
article
Author
Prabir K. Chakraborty; Soumyajit Banerjee Mustafi; Xunhao Xiong; Shailendra Kumar Dhar Dwivedi; Vasyl Nesin; Sounik Saha; Min Zhang; Danny Dhanasekaran; Muralidharan Jayaraman; Robert Mannel; Kathleen Moore; Scott McMeekin; Da Yang; Rosemary Zuna; Kai Ding; Leonidas Tsiokas; Resham Bhattacharya; Priyabrata Mukherjee
Source
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
The mitochondrial uniporter MICU1 regulates mitochondrial Ca2+ uptake. Here, the authors show that MICU1 is upregulated in ovarian cancer and confers resistance to cisplatin-induced apoptosis through a Ca2+-mediated regulation of pyruvate dehydrogenase activity that results in increased glycolysis.