학술논문
Causes of death in women with breast cancer: a risks and rates study on a population-based cohort
Document Type
article
Author
Paolo Contiero; Roberto Boffi; Alessandro Borgini; Sabrina Fabiano; Andrea Tittarelli; Michael Mian; Fabio Vittadello; Susi Epifani; Antonino Ardizzone; Claudia Cirilli; Lorenza Boschetti; Stefano Marguati; Giuseppe Cascone; Rosario Tumino; Anna Clara Fanetti; Paola Giumelli; Giuseppa Candela; Tiziana Scuderi; Maurizio Castelli; Salvatore Bongiorno; Giulio Barigelletti; Viviana Perotti; Chiara Veronese; Fabio Turazza; Marina Crivaro; Giovanna Tagliabue; the MAPACA Working Group
Source
Frontiers in Oncology, Vol 13 (2023)
Subject
Language
English
ISSN
2234-943X
Abstract
IntroductionThe increasing survival of patients with breast cancer has prompted the assessment of mortality due to all causes of death in these patients. We estimated the absolute risks of death from different causes, useful for health-care planning and clinical prediction, as well as cause-specific hazards, useful for hypothesis generation on etiology and risk factors.Materials and methodsUsing data from population-based cancer registries we performed a retrospective study on a cohort of women diagnosed with primary breast cancer. We carried out a competing-cause analysis computing cumulative incidence functions (CIFs) and cause-specific hazards (CSHs) in the whole cohort, separately by age, stage and registry area.ResultsThe study cohort comprised 12,742 women followed up for six years. Breast cancer showed the highest CIF, 13.71%, and cardiovascular disease was the second leading cause of death with a CIF of 3.60%. The contribution of breast cancer deaths to the CIF for all causes varied widely by age class: 89.25% in women diagnosed at age