학술논문
Right ventricular-arterial uncoupling independently predicts survival in COVID-19 ARDS
Document Type
article
Author
Michele D’Alto; Alberto M. Marra; Sergio Severino; Andrea Salzano; Emanuele Romeo; Rosanna De Rosa; Francesca Maria Stagnaro; Gianpiero Pagnano; Raffaele Verde; Patrizia Murino; Andrea Farro; Giovanni Ciccarelli; Maria Vargas; Giuseppe Fiorentino; Giuseppe Servillo; Ivan Gentile; Antonio Corcione; Antonio Cittadini; Robert Naeije; Paolo Golino
Source
Critical Care, Vol 24, Iss 1, Pp 1-10 (2020)
Subject
Language
English
ISSN
1364-8535
Abstract
Abstract Aim To investigate the prevalence and prognostic impact of right heart failure and right ventricular-arterial uncoupling in Corona Virus Infectious Disease 2019 (COVID-19) complicated by an Acute Respiratory Distress Syndrome (ARDS). Methods Ninety-four consecutive patients (mean age 64 years) admitted for acute respiratory failure on COVID-19 were enrolled. Coupling of right ventricular function to the pulmonary circulation was evaluated by a comprehensive trans-thoracic echocardiography with focus on the tricuspid annular plane systolic excursion (TAPSE) to systolic pulmonary artery pressure (PASP) ratio Results The majority of patients needed ventilatory support, which was noninvasive in 22 and invasive in 37. There were 25 deaths, all in the invasively ventilated patients. Survivors were younger (62 ± 13 vs. 68 ± 12 years, p = 0.033), less often overweight or usual smokers, had lower NT-proBNP and interleukin-6, and higher arterial partial pressure of oxygen (PaO2)/fraction of inspired O2 (FIO2) ratio (270 ± 104 vs. 117 ± 57 mmHg, p