학술논문
Dysglycemia in young women attenuates the protective effect against fatty liver disease
Document Type
article
Author
Source
Frontiers in Endocrinology, Vol 13 (2022)
Subject
Language
English
ISSN
1664-2392
Abstract
IntroductionSexual dimorphism has been reported in non-alcoholic fatty liver disease (NAFLD), similar to the sex differences evident with cardiovascular disease. Type 2 diabetes mellitus (T2D) significantly increases the risk and severity of NAFLD, but there is scarce information on whether T2D or altered glucose metabolism can modify the prevalence of NAFLD in men and women of reproductive age.PurposeTo investigate the relationship between age, sex and NAFLD in subjects with and without dysglycemia.Materials and methodsWe analyzed 2,790 patients. NAFLD was characterized using established diagnostic criteria: one or more positive results on the fatty liver index and hepatic ultrasound. Liver fibrosis (liver stiffness measurement [LSM] ≥8.0 kPa) was assessed by Fibroscan®. For analysis purposes, we included both T2D and prediabetes under the predefined condition of dysglycemia.ResultsThe global prevalence of NAFLD was higher in men than in women (50% and 34%; P