학술논문
Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia
Document Type
article
Author
Celso Arrais Rodrigues; Matheus Vescovi Gonçalves; Maura Rosane Valério Ikoma; Irene Lorand-Metze; André Domingues Pereira; Danielle Leão Cordeiro de Farias; Maria de Lourdes Lopes Ferrari Chauffaille; Rony Schaffel; Eduardo Flávio Oliveira Ribeiro; Talita Silveira da Rocha; Valeria Buccheri; Yuri Vasconcelos; Vera Lúcia de Piratininga Figueiredo; Carlos Sérgio Chiattone; Mihoko Yamamoto
Source
Revista Brasileira de Hematologia e Hemoterapia, Vol 38, Iss 4, Pp 346-357
Subject
Language
English
ISSN
1806-0870
Abstract
ABSTRACT Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19+, CD5+ and CD23+. The lymphocytes usually infiltrate the bone marrow, peripheral blood, lymph nodes, and spleen. The diagnosis is established by immunophenotyping circulating B-lymphocytes, and prognosis is defined by two staging systems (Rai and Binet) established by physical examination and blood counts, as well as by several biological and genetic markers. In this update, we present the recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia for the diagnosis and treatment of chronic lymphocytic leukemia. The following recommendations are based on an extensive literature review with the aim of contributing to more uniform patient care in Brazil and possibly in other countries with a similar social-economic profile.