학술논문
Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination
Document Type
article
Author
Evi van Schuppen; Janeri Fröberg; Prashanna Balaji Venkatasubramanian; Pauline Versteegen; Hans de Graaf; Jana Holubová; Joshua Gillard; Pieter G. M. van Gageldonk; Irma Joosten; Ronald de Groot; Peter Šebo; Guy A. M. Berbers; Robert C. Read; Martijn A. Huynen; Marien I. de Jonge; Dimitri A. Diavatopoulos
Source
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Bordetella pertussis (Bp), the causative agent of pertussis, continues to circulate and it’s not well understood how (sub)clinical infections shape immune memory to Bp and vaccination. Here, using a mutant Bp strain lacking antigens of the acellular pertussis vaccine, the authors show how prior exposure to Bp shapes the mucosal antibody response to booster vaccination.