부산대학교 도서관

Properties of pore structure in Metal-organic frameworks (MOFs) play a key role in the adsorption of target molecules hence are used to improve the efficiency in MOFs. In this study, we synthesized three MOFs with different hydrophilicity, namely TMU-6(RL1), TMU-21(RL2) and TMU-59. Additionally, we studied the effect of hydrophobicity/hydrophilicity of pore in MOFs on the drug delivery and sensing properties. The structure of these frameworks was characterized by XPS, BET, XRD, IR and TG. The DLC and DLE of TMU-6(RL1), TMU-21(RL2) and TMU-59, were determined by (20%, 70%), (18%, 78%) and (3.6%, 13.6%), respectively. Also, the curcumin release reached 74%, 57% and 8% respectively for TMU-6(RL1), TMU-21(RL2) and TMU-59 after 100 h in PBS solution with pH 7.2 respectively. The carriers showed high adsorption efficiency and controlled release. Adsorption of curcumin as an anticancer drug to the MOFs was done through multiple mechanisms such as Hostπ–πGuest interaction and HostN–H⋯OGuest hydrogen bonds. Also, studies of in vitro anticancer revealed that the cytotoxicity of the MOFs@Curcumin composites against HT-29 cancer cells in MOFs was more than free curcumin. The findings demonstrated that the changes in the hydrophilic properties of frameworks can specifically control the Host-Guest interactions, drug loading and its release.