학술논문
LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes
Document Type
article
Author
Source
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Herdenberg et al. show that adipogenesis and BMP signaling are altered in mouse cells deficient in LRIG (Leucine-rich repeats and immunoglobulin-like domains) proteins. They find that mutant LRIG/sma-10 variant worms exhibit lipid storage defects and that human LRIG1 variants are associated with higher body mass index, yet protect against type 2 diabetes. This study suggests an evolutionarily conserved role of LRIG proteins for lipid metabolism and BMP signaling.