학술논문
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma
Document Type
article
Author
Lorey K. Smith; Tiffany Parmenter; Margarete Kleinschmidt; Eric P. Kusnadi; Jian Kang; Claire A. Martin; Peter Lau; Riyaben Patel; Julie Lorent; David Papadopoli; Anna Trigos; Teresa Ward; Aparna D. Rao; Emily J. Lelliott; Karen E. Sheppard; David Goode; Rodney J. Hicks; Tony Tiganis; Kaylene J. Simpson; Ola Larsson; Benjamin Blythe; Carleen Cullinane; Vihandha O. Wickramasinghe; Richard B. Pearson; Grant A. McArthur
Source
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Different adaptive mechanisms have been reported to reduce the efficacy of mutant BRAF inhibition in melanoma. Here, the authors show BRAF inhibition induces the translational regulation of metabolic genes leading to acquired therapy resistance.