학술논문
Dysregulated transcriptional responses to SARS-CoV-2 in the periphery
Document Type
article
Author
Micah T. McClain; Florica J. Constantine; Ricardo Henao; Yiling Liu; Ephraim L. Tsalik; Thomas W. Burke; Julie M. Steinbrink; Elizabeth Petzold; Bradly P. Nicholson; Robert Rolfe; Bryan D. Kraft; Matthew S. Kelly; Daniel R. Saban; Chen Yu; Xiling Shen; Emily M. Ko; Gregory D. Sempowski; Thomas N. Denny; Geoffrey S. Ginsburg; Christopher W. Woods
Source
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The systemic immune features that distinguish COVID-19 from common infections remain incompletely elucidated. Here McClain et al. compare RNA sequencing in peripheral blood between subjects with SARS-CoV-2 and other respiratory infections and demonstrate dysregulated immune responses in COVID-19 with both heterogeneous and conserved components.